vildagliptin tablet galvus  (Novartis)

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: Chemical structure of vildagliptin (( 2S )-1-{[(3-hydroxytricyclo[3.3.1.13,7]-decan-1-yl)amino]acetyl}pyrrolidine-2-carbonitrile).

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques:

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: Parameters of LC-UV method for the quantitative determination of vildagliptin.

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques:

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: The percentage level of degradation and kinetic parameters for the degradation of vildagliptin in solutions.

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques:

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: Pseudo first-order plots of degradation of vildagliptin in solutions at 23 °C (mean ± SD, n = 3 for each time point).

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques:

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: Related substances of vildagliptin described in the literature.

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques:

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: Degradation products of vildagliptin detected by our UHPLC-DAD-MS method.

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques:

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: Products of degradation of vildagliptin in acidic, basic and oxidative conditions.

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques:

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: UHPLC-DAD-MS2 data of the detected compounds in the analyzed samples.

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques:

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: BPC MS+ chromatograms of the analyzed samples. V=vildagliptin, A, B, C, D = Compounds A–D (degradation products of vildagliptin) and Imps 1–3.

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques:

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: MS and UV/VIS spectra of vildagliptin (V).

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques:

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: Mid-IR characteristics of vildagliptin, lactose (LAC), mannitol (MAN), magnesium stearate (MGS) and polyvinylpirrolidone (PVP).

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques:

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: ( A – D ) PCA scores plots of mid-IR spectra of vildagliptin (Pure Drug) and the mixtures of vildagliptin with Excipients: ( A ) lactose (LAC), ( B ) mannitol (MAN), ( C ) magnesium stearate (MGS) and ( D ) polyvinylpirrolidone (PVP).

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques:

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: ( A – D ) PCA scores plots of NIR spectra of vildagliptin (Pure Drug) and the mixtures of vildagliptin with Excipients: ( A ) lactose (LAC), ( B ) mannitol (MAN), ( C ) magnesium stearate (MGS) and ( D ) polyvinylpirrolidone (PVP).

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques:

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: ( A – C ) Vildagliptin and lactose (LAC): mid-IR spectra of no stressed mixture ( A ), stressed mixture ( B ) and PCA loadings of the spectra ( C ); PC1 loadings are marked black while PC2 loadings are marked red; most visible differences in the spectrum of the stressed mixture are indicated with circles.

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques:

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: ( A – C ) Vildagliptin and lactose (LAC): NIR spectra of no stressed mixture ( A ), stressed mixture ( B ) and PCA loadings of the spectra ( C ); PC1 loadings are marked black while PC2 loadings are marked red; most visible differences in the spectrum of the stressed mixture are indicated with circles.

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques:

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: ( A – C ) Vildagliptin and mannitol (MAN): mid-IR spectra of no stressed mixture ( A ), stressed mixture ( B ) and PCA loadings of the spectra ( C ); PC1 loadings are marked black while PC2 loadings are marked red; most visible differences in the spectrum of the stressed mixture are indicated with circles.

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques:

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: ( A – C ) Vildagliptin and mannitol (MAN): NIR spectra of no stressed mixture ( A ), stressed mixture ( B ) and PCA loadings of the spectra ( C ); PC1 loadings are marked black while PC2 loadings are marked red, most visible differences in the spectrum of the stressed mixture are indicated with circles.

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques:

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: ( A – C ) Vildagliptin and magnesium stearate (MGS): mid-IR spectra of no stressed mixture ( A ), stressed mixture ( B ) and PCA loadings of the spectra ( C ); PC1 loadings are marked black while PC2 loadings are marked red, most visible differences in the spectrum of the stressed mixture are indicated with circles.

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques:

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: ( A – C ) Vildagliptin and magnesium stearate (MGS): NIR spectra of no stressed mixture ( A ), stressed mixture ( B ) and PCA loadings of the spectra ( C ); PC1 loadings are marked black while PC2 loadings are marked red; most visible differences in the spectrum of the stressed mixture are indicated with circles.

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques:

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: ( A – C ) Vildagliptin and polyvinylpirrolidone (PVP): mid-IR spectra of no stressed mixture ( A ), stressed mixture ( B ) and PCA loadings of the spectra ( C ); PC1 loadings are marked black while PC2 loadings are marked red; most visible differences in the spectrum of the stressed mixture are indicated with circles.

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques:

Journal: Molecules

Article Title: Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA)

doi: 10.3390/molecules26185632

Figure Lengend Snippet: ( A – C ) Vildagliptin and polyvinylpirrolidone (PVP): NIR spectra of no stressed mixture ( A ), stressed mixture ( B ) and PCA loadings of the spectra ( C ); PC1 loadings are marked black while PC2 loadings are marked red; most visible differences in the spectrum of the stressed mixture are indicated with circles.

Article Snippet: Galvus ® tablets containing 50 mg of vildagliptin were produced by Novartis Europharm (Basel, Switzerland).

Techniques: